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Immunosuppressive Properties of α 1 ‐Microglobulin
Author(s) -
LöGDBERG L.,
ÅKERSTRöM B.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00148.x
Subject(s) - phytohaemagglutinin , concanavalin a , alpha (finance) , microbiology and biotechnology , toxoid , cytotoxicity , chemistry , beta 2 microglobulin , antiserum , stimulation , antigen , immunology , biology , immune system , biochemistry , endocrinology , in vitro , medicine , immunization , construct validity , nursing , patient satisfaction
α 1 ‐Microglobulin (α 1 m), a serum glycoprotein (26,000 d). was found to impede the proliferative response of human lymphocytes to purified protein derivative (PPD) and tetanus toxoid. The data suggest that, α 1 m operates through an unstable suppressor mechanism, which no longer can function after 24 h of preculturing. This effect of α 1 m on antigen stimulation did not seem to be due to binding of α 1 m to PPD or cells, to altered kinetics of the PPD response, or to non‐specific cytotoxicity. In contrast, PPD‐induced leucocyte migration inhibition was not reversed by α 1 m. α 1 m did not cause significant inhibition in experiments in which lymphocytes were stimulated by the mitogens phytohaemagglutinin or concanavalin A. Finally, α 1 m had its own leucocyte migration inhibitory effect.