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Selective Enhancement of Human Mononuclear Leucocyte Cytotoxic Function by Interferon
Author(s) -
KIMBER I.,
MOORE M.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00147.x
Subject(s) - antibody dependent cell mediated cytotoxicity , peripheral blood mononuclear cell , cytotoxic t cell , immunology , interferon , lymphocyte , monocyte , cytotoxicity , k562 cells , population , effector , biology , interferon gamma , antibody , chemistry , cytokine , medicine , in vitro , biochemistry , monoclonal antibody , leukemia , environmental health
The influence of type I interferon (1FN) on leucocyte‐mediated antibody‐dependent cellular cytotoxicity (ADCC) has been examined in a system in which differential alloantibody sensitization of human erythrocyte target cells allows discrimination between lymphocyte and monocyte effector function. ADCC mediated by unfractionated mononuclear leucocyte populations was regularly enhanced by interferon pretreatment over a range of concentrations of the sensitizing antibody. The capacity for IFN‐augmented reactivity was, however, removed with adherent cell depletion, suggesting that lymphocyte (K‐cell)effectors are not modulated by IFN, even though such population demonstrate IFN‐potentiated natural killer (NK) reactivity against K562. These results suggest that monocyte and NK cell function but not K‐cell activity arc influenced by interferon.