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Experimentally Induced Transplantation Tolerance
Author(s) -
WATERFIELD J. D.,
BICK P. H.,
MÖLLER E.,
MÖLLER G.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00127.x
Subject(s) - graft vs host reaction , effector , in vivo , spleen , cytotoxic t cell , in vitro , immunology , transplantation , biology , immune tolerance , histocompatibility , immunologic tolerance , major histocompatibility complex , microbiology and biotechnology , antigen , medicine , human leukocyte antigen , bone marrow , bone marrow transplantation , genetics
Neonatal tolerance was induced in CBA mice to alloantigens expressed by lymphoid cells of the A/Sn strain. 50% of the grafted animals maintained viable skin grafts for greater than 120 days and thus were considered operationally tolerant. However, splenic lymphocytes from these animals were capable of in vitro activation of DNA synthesis in response to the tolerizing alloantigens Likewise, the spleen contained precursors of Cytotoxic effector cells capable, upon activation of similarly recognizing the major histocompatibility complex alloantigens used for tolerance induction. In contrast, in vivo graft‐versus‐host (GVH) effector function was absent, suggesting a possible dissociation of cells involved in the in vitro cell‐mediated lympholysis and the in vivo GVH. Determination of potential serum‐blocking factors as a possible mechanism of graft survival in these tolerant animals proved negative.