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Allogeneic H‐2 does not Cross‐react, at the Helper T‐Cell Level, with Hapten‐modified Self
Author(s) -
MARTINEZ C.,
COUTINHO A.,
BERNABÉ R. R
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00109.x
Subject(s) - hapten , in vitro , t cell , chemistry , immunology , microbiology and biotechnology , spleen , biology , cell , antigen , biochemistry , immune system
Helper T cell raised in CBA mice and enriched in vitro with specificity for trinitrophenylmodified syngeneic spleen cells can activate hapten‐modified B cells bearing I k . These helper cells fail to activate B cells expressing any of six independent I‐region haplotypes, indicating lack of cross‐reactivity between hapten‐self and allogeneic I‐region products, Furthermore, hapten‐derivatized allogeneic B sells are also not activated, demonstrating that the elements restricting T‐cell function are poorly, if at all, cross‐reactive.