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Thymus Cells Suppress the in Vitro Cytotoxic Response against Trinitrophenyl (TNP) Modified Syngeneic Cells
Author(s) -
HURME M.,
BANG B. E.
Publication year - 1981
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1981.tb00108.x
Subject(s) - cytotoxic t cell , in vitro , spleen , cytotoxicity , biology , microbiology and biotechnology , immunology , lymph node , mitomycin c , cancer research , chemistry , biochemistry , genetics
The regulatory role of adult thymocytes in the in vitro cytotoxic cell formation against TNP‐coupled syngeneic spleen cells was studied. Thymocytes are known to amplify the cytotoxic response of lymph node cells against allogeneic cells. This kind of synergism was nut found in the response against TNP‐coupled cells: on the contrary, thymocytes had a clear suppressive effect. Thymocytes inducing this suppression must be present already at the beginning of the In vitro response. Mitotically blocked (mitomycin‐C treated) thymocytes but not heat killed or lysed cells were also capable to suppress anti‐TNP cytotoxicity.