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Effect of CBA/N xid on Spontaneous Production of Antibodies to DNA in MRL/1 and NZB Backcross Mice
Author(s) -
COWDERY J. S.,
TAUROG J. D.,
STEINBERG A. D.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00097.x
Subject(s) - bruton's tyrosine kinase , backcrossing , antibody , dna , biology , offspring , microbiology and biotechnology , genetics , gene , immunology , pregnancy , signal transduction , tyrosine kinase
We have used the CBA/N X‐linked B‐cell maturation defect ( xid ) as a probe to analyse the B‐cell subset involved in spontaneous anti‐DNA production in MRL/1 and NZB mice. The presence of xid in NZB offspring significantly suppressed anti‐DNA production, whereas it did not suppress spontaneously produced antibody to DNA in MRL/1 offspring. These studies suggest that largely non‐overlapping B‐cell subsets are responsible for the spontaneous production of anti‐DNA in MRL/1 and NZB mice.