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Separation and Functional Analysis of Subpopulations of T Cells in the Bone Marrow of the Mouse
Author(s) -
RÖPKE C.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00075.x
Subject(s) - bone marrow , cell , chemistry , microbiology and biotechnology , fractionation , biology , immunology , biochemistry , chromatography
Functional capacities of T‐cell precursors have been evaluated by cell culture experiments after fractionation of bone marrow cells from normal and nude mice by 1 g velocity sedimentation. The results indicate that the T‐cell precursors in the bone marrow are cycling cells, that T‐cell precursors in the bone marrow of nude mice have more limited potentials than those of normal mice, and that both Thy‐1.2‐positive and Thy‐1.2‐negative precursors are stimulated by T‐cell activators.

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