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T‐Cell Functions in Nude Mice: Proliferation of Spleen Cells from Athymic Mice in the One‐way Xenogeneic Mixed Leucocyte Reaction
Author(s) -
HAMMARSTRÖM L.,
SMITH C. I. E.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00061.x
Subject(s) - in vitro , spleen , biology , microbiology and biotechnology , cell , digitalis , immunology , chemistry , biochemistry , medicine , heart failure
Spleen cells from nude mice proliferate in vitro when stimulated with xenogeneic (human) lymphoid cells rendered unresponsive by addition of digitalis glycosides. In digitalis‐sensitive species, such as humans. DNA, RNA, carbohydrate, and protein synthesis is completely blocked by addition of low concentrations of glycoside, whereas no impairment is found in digitalis‐resistant species such as mouse. Since T cells have been implicated to be the cells responding in the mixed leucocyte reaction, this finding may suggest the occasional existence of ‘T‐like’ cells in the spleens of nude mice.