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A Gene of the Immunoglobulin H‐Chain Cluster Controls the Murine Antibody Response to Pneumococcal Polysaccharide Type 14
Author(s) -
MÄKELÄ O.,
PASANEN V. J.,
SARVAS H.,
LEHTONEN M.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00052.x
Subject(s) - antibody , biology , gene , congenic , antibody response , virology , polysaccharide , microbiology and biotechnology , serology , immunology , genetics , biochemistry
Mice of various strains were immunized with pneumococcal polysaccharide type 14 (pneumo‐14), and their anti‐pneumo‐14 antibodies were measured by the Farr test. Mice of strains BALB/c, ST/b, NZB and CBA (Ig allotypes a, e or J) had 300–1700 ng of antibody nitrogen per millilitre of serum on day 7. The corresponding values for C57BL/Ka, RF or AKR mice (allotypes b, c or d) were 40–300 ng/ml. Two families of congenic strains were tested, one with the C57BL and the other with the BALB/c background genome. Their response was either high or low depending on the V H genes, and other gene loci had little effect on the concentration of anti‐pneumo‐14 antibodies.