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HLA‐DR‐like Antigens in the Epithelium of the Human Small Intestine
Author(s) -
SCOTT H.,
SOLHEIM B. G.,
BRANDTZAEG P.,
THORSBY E.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00043.x
Subject(s) - lamina propria , epithelium , antigen , gastrointestinal tract , biology , pathology , small intestine , staining , immunofluorescence , antiserum , histiocyte , microbiology and biotechnology , antibody , immunology , medicine , biochemistry
Sections of ethanol‐fixed, paraffin‐embedded tissue specimens from different parts of the human gastrointestinal tract were stained by an indirect immunofluorescence method with a rabbit antiserum to HLA‐DR‐antigens from B lymphocytes. A specific staining reaction was seen in a patchy pattern apically in the columnar cells of the normal small intestine, decreasing in intensity from the top of the villi towards the crypts. No HLA‐DR‐like antigens could he detected in colon or stomach epithelium, whereas cellS with the morphology of lymphocytes and histiocytes in the lamina propria and also capillary walls were specifically stained throughout the gastrointestinal tract.