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Lymphocyte Transformation in Nickel Allergy: Amplification of T‐lymphocyte Responses to Nickel Sulphate by Macrophages in Vitro
Author(s) -
SILVENNOINENKASSINEN S.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00041.x
Subject(s) - phytohaemagglutinin , pokeweed mitogen , concanavalin a , immunology , nickel allergy , tuberculin , stimulation , microgram , lymphocyte , medicine , t lymphocyte , allergy , cellular immunity , in vitro , contact dermatitis , immune system , chemistry , tuberculosis , pathology , biochemistry
The cell‐mediated immunity of thirty‐four nickel contact dermatitis patients was evaluated by performing lymphocyte stimulations with NiSO 4 (1.25 and 6.25 μg/ml) and tuberculin (PPD), phytohaemagglutinin‐P, pokeweed mitogen, and concanavalin A. Twenty‐six of the patients were nonatopic and eight atopic. Forty‐nine healthy subjects served us controls. Nickel sulphate stimulation was significantly increased ( P <0.005) In the allergic subjects, whereas stimulation was decreased ( P =0.01). The responses to the other mitogens did not differ significantly between the control subjects and the patients. The lymphocyte transformation reaction to nickel sulphate was shown to occur in T cells and to be enhanced by the helper function of macrophages.