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HLA‐D/DR Restriction of Macrophage‐dependent Antigen Activation of Immune T Lymphocytes: Cross‐reacting Allogeneic HLA‐D/DR May Partly Substitute for Self HLA‐D/DR
Author(s) -
BERGHOLTZ B. O.,
THORESEN A. B.,
THORSBY E.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00022.x
Subject(s) - immunology , antigen , macrophage , human leukocyte antigen , tuberculin , serology , t cell , immune system , t lymphocyte , cytotoxic t cell , in vitro , biology , medicine , antibody , tuberculosis , pathology , genetics
Optimal proliferative response of T lymphocytes to purified protein derivative of tuberculin (PPD) III vitro requires that antigen be presented by autologous macrophages or allogeneic macrophages sharing HLA‐D/DR determinants with the T cell donor. In some cases, however, T cells may respond to a limited extent to PPD in association with macrophages expressing different HLA‐D/DR determinants. In this paper experiments are presented where various combinations of T cells and HLA‐D/DR disparate macrophages were stimulated with PPD. We often found a stronger PPD‐specific response in HLA‐D/DR‐incompatible combinations in which the macrophages carried HLA‐DR antigens known from serological studies to be cross‐reactive with those of the T cell donor than in combinations in which this was not the case. Thus, the cross‐reactions detected by serology may sometimes be reflected on a functional level in T lymphocyte/macrophage cooperation.