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An Inherited Restriction in the Idiotypic Variability as a Possible Explanation of a Genetic Predisposition for a Monoclonal Component
Author(s) -
OCKHUIZEN TH.,
DEENEN G. J.,
BALEN I. M.,
MANDEMA E.,
MARRINK J.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00019.x
Subject(s) - antigenicity , monoclonal gammopathy , antiserum , biology , monoclonal , genetic predisposition , genetics , idiotype , immunology , monoclonal antibody , genetic variability , genotype , antigen , antibody , gene
Genetic factors have been proposed to play a role in the actiology of a monoclonal proliferation of H lymphocytes. As an additional genetic factor we postulate that a restriction in the idiotypic variability of an indivisual contributes to a genetic predisposition to monoclonal gammopathy. To support our hypothesis, we have examined three families with multiple occurrence of M‐components for sharing of idiotypic antigenicity between the related M‐components and between the M‐components and the sera of unaffected relatives. Idiotypic antisera against five isolated M‐components were raised in guinea‐pigs and used in a radiobinding inhibition assay. In none of the three families was idiotypic cross‐reactivity observed between the familial M‐components. However, in a family with three members with an M‐component, sera of first‐degree relatives showed a higher inhibitory capacity than sera of non‐related individuals when an idiotypic antiserum, raised against the M‐component of proposita, was employed. Within this particular family the observed restriction in the idiotypic variability could have contributed to the multiple occurrence of M‐components.