Premium
Studies of Anti‐Lymphocyte Antibody in Patients with Active SLE
Author(s) -
MORIMOTO C.,
ABE T.,
TOGUCHI T.,
KIYOTAKI M.,
HOMMA M.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00016.x
Subject(s) - autoantibody , immunology , antibody , lymphocyte , antigen , immune system , suppressor , t lymphocyte , dna , biology , medicine , gene , genetics
The effect of anti‐lymphocyte antibodies of active systemic lupus erythematosus (SLE) on the immune regulation of autoantibody production was studied. The present study demonstrated that there were native DNA (nDNA)‐sensitized T lymphocytes even in inactive SLE and no or few nDNA‐sensitized T lymphocytes in normal individuals, and that in the inactive stages of SLE suppressor T lymphocytes might inhibit the activation of nDNA‐sensitized T lymphocytes eliciting the production of anti‐DNA antibodies by B lymphocytes. In the active stage of SLE, the anti‐lymphocyte antibodies could eliminate the suppressor function of T lymphocytes or a subset of cells capable of either regulating their appearance or differentiating into them, which inhibited such responses. The different suppression of DNA and extractable nuclear antigen (ENA)‐stimulated blastogenic response is further discussed.