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Lymphoid Stem Cells in the Intraembryonic Mesenchyme of the Chicken
Author(s) -
LASSILA O.,
ESKOLA J.,
TOIVANEN P.,
DIETERLENLIÈVRE F.
Publication year - 1980
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1980.tb00011.x
Subject(s) - mesenchyme , yolk sac , biology , immunology , stem cell , microbiology and biotechnology , andrology , bone marrow , progenitor cell , embryo , medicine
Chromosomally marked cells from the 7‐day intraembryonic mesenchyme were transplanted into 14‐day‐old irradiated chick embryos. At the age of 6 weeks donor‐derived T and B lymphocytes were shown to be present in the thymus, spleen and bone marrow, indicating that cells in the 7‐day intraembryonic mesenchyme are capable of developing into functional T and B lymphocytes. In addition to the sex chromosome marker, IgG allotype was used as a marker; the results demonstrate that cells from intraembryonic haemopoietic sites develop into mature IgG‐producing cells. In similar experiments, the 7‐day yolk sac also proved to contain lymphoid stem cells. Since lymphoid cell progenitors are not present in the 2‐day yolk sac, as has been shown previously in the yolk sac‐embryo chimaeras and since circulation is established from day 2 of incubation onwards, lymphoid stem cells present in the 7‐day yolk sac are most likely secondary immigrants originating in the intraembryonic mesenchyme.