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Lymphocyte Subpopulations in Man: Characterization of Human Killer Cells against Allogeneic Targets Sensitized with HLA Antibodies
Author(s) -
JOHNSEN H. E.,
MADSEN M.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb03065.x
Subject(s) - cytotoxic t cell , immunology , antibody , avidity , cytotoxicity , biology , lymphoblast , effector , receptor , human leukocyte antigen , microbiology and biotechnology , antigen , cell culture , in vitro , biochemistry , genetics
Human killer cells mediating antibody‐dependent cytotoxicity against allogeneic lymphoblasts presensitized with HLA antibodies have been studied by rosette fractionation experiments. Enriched and/or depleted cell suspensions have been tested in dose–response studies. Two different populations can act as killer cells. The major cytotoxic capacity is retained among T cells with high‐avidity Fc receptors, whereas a minor cytotoxic capacity was found among non‐T cells with high‐avidity Fc receptors. These two populations have different dose‐response curves, indicating different effector mechanisms.