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Lymphocyte Subpopulations in Man: Relationship between Four Subpopulations Identified by Membrane Markers
Author(s) -
JOHNSEN H. E.,
MADSEN M.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb03064.x
Subject(s) - avidity , receptor , antibody , biology , immunology , complement receptor , population , lymphocyte , antigen , microbiology and biotechnology , complement system , biochemistry , medicine , environmental health
The interrelationship between four Subpopulations of human lymphocytes was studied in eight normal persons, Double marking and fractionation experiments established that lymphocytes with receptors for AET‐treated sheep erythrocytes constitute a population complementary to cells that carry surface membrane immunoglobulins as they are identified by polyvalent rabbit anti‐human immunoglobulin: the latter includes nearly all tells with complement receptors. Two functionally different receptors for antigen‐bound IgG are identified by their binding avidity for rabbit‐antibody‐sensitized ox erythrocytes, defining populations of lymphocytes with high‐avidity and low‐avidity receptors, indicating two valuable differentiation markers.