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The V K VI Subgroup of Rabbit Light Chains: Complete Amino Acid Sequence of a Third Variable Region (K29–213)
Author(s) -
HUSER H.,
BRAUN D.G.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb02712.x
Subject(s) - sequence (biology) , chemistry , amino acid , microbiology and biotechnology , stereochemistry , biology , biochemistry
The amino acid sequence of the variable region of a rabbit anti‐streptococcal A‐variant antibody light chain was determined. By using a combination of different cleavage methods, the sequence was established. Large peptides were sequenced in an extensively modified Beckman sequenator. Light chain K29–213 belongs to a rare subgroup ( K VI). Several of these light chains of antibodies with different specificities have been totally or partially sequenced. Comparison of these light chains reveals at least four germ‐line‐encoded variants within this subgroup.