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Rheumatoid Synovial Lymphocytes Lack Concanavalin‐A‐activated Suppressor Cell Activity
Author(s) -
CHATTOPADHYAY C.,
CHATTOPADHYAY H.,
NATVIG J. B.,
MELLBYE O. J.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb01378.x
Subject(s) - concanavalin a , suppressor , rheumatoid arthritis , juvenile rheumatoid arthritis , medicine , psoriatic arthritis , arthritis , immunology , lymphocyte , synovial membrane , synovial fluid , pathology , biology , in vitro , osteoarthritis , biochemistry , cancer , alternative medicine
Synovial lymphocytes eluted by enzyme treatment from eleven patients with rheumatoid arthritis (RA) were investigated for the presence of concanavalin A (Con A)‐activated suppressor cell activity as compared with that of peripheral blood lymphocytes of twenty normal donors. In addition, two patients with psoriatic arthritis and juvenile rheumatoid arthritis (JRA) were also investigated. Synovial lymphocytes from the eleven RA patients showed a mean augmentation of 28±13.30, and thus clearly lacked suppressor activity, whereas the mean suppression in the lymphocytes from the twenty normal donors was 13 ±14.40. Synovial lymphocytes from one patient with JRA and one with psoriatic arthritis showed a normal suppressor activity.