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Mitogen‐induced Differentiation of Human CLL Lymphocytes to Antibody‐secreting Cells
Author(s) -
ROBÈRT K.H.,
BIRD A. G.,
MÖLLER E.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb01374.x
Subject(s) - pokeweed mitogen , antibody , immunology , mitogen activated protein kinase , dna synthesis , biology , virology , dna , microbiology and biotechnology , peripheral blood mononuclear cell , in vitro , genetics , signal transduction
Peripheral blood lymphocytes from nine patients with chronic lymphatic leukaemia (CLL) have been stimulated by photohaemagglutinin, pokeweed mitogen and Epstein‐Barr virus. Our results provide proof that the leukaemic B cells in CLL are capable of responding to mitogenic signals by producing and secreting antibodies, transforming into blast cells, and, probably, increasing their rate of DNA synthesis.