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The Availability for Recognition of Normal H‐2 Antigens by Cytotoxic T Lymphocytes on a Rauscher‐Virus‐transformed Cell, RBL‐5A
Author(s) -
WATSON A.,
ZARLING D. A.,
BACH F. H.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb01363.x
Subject(s) - antigen , cytotoxic t cell , biology , in vitro , microbiology and biotechnology , cell , mutant , virus , cell culture , virology , immunology , chemistry , gene , genetics
The availability for recognition of cell surface H‐2D b antigenic determinants on RBL‐5A cells in comparison to normal C57BL/6 cells was investigated by an in vitro immunological assay. No differences in the immunological recognition of the H‐2D b antigens on RBL‐5A cells compared to normal C57BL/6 cells were detected. This assay system, however, readily detected changes in the H‐2K b determinant profile an target cells from the C37BL/6 H‐2K b region mutant strains H(z1) and H(z170) when compared to normal C57BL/6 mice. The result obtained with RBL‐5A target cells therefore suggests that Rauscher murine leukaemia virus transformation does not induce, either genotypically or phenotypically, an immunologically recognizable alteration of the H‐2D b antigen profile on this cell.