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A High Frequency of Cytotoxic Precursor Cells for a Syngeneic Tumour
Author(s) -
WARREN H. S.,
LAFFERTY K. J.
Publication year - 1979
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1979.tb01362.x
Subject(s) - cytotoxic t cell , lymph node , immunogenicity , in vitro , precursor cell , immunology , biology , cancer research , cytotoxicity , chemistry , pathology , immune system , medicine , biochemistry
The average frequency of cytotoxic precursor cells in DBA/2 lymph node cell preparations reactive to the syngeneic tumour P815 has been determined as 1 in 2000. This frequency is similar to the precursor frequency for an allogeneic tumour EL‐4. The normal lack of response of DBA/2 lymph node cells to the syngeneic tumour P815 in vitro cannot be attributed to a lack of cytotoxic precursor cells. We conclude that in this tumour‐host system non‐immunogenicity reflects a defect at the inductive step.