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Novel Gamma‐glutamyl Transpeptidase Isoenzyme Occurring in Sera of Patients with Hepatoma
Author(s) -
HATTORI N.,
SAWABU N.,
NAKAGEN M.,
ISHII M.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb03968.x
Subject(s) - isozyme , ceruloplasmin , carcinoembryonic antigen , gtp' , polyacrylamide gel electrophoresis , medicine , microbiology and biotechnology , chemistry , gastroenterology , gamma glutamyltransferase , pathology , biology , enzyme , biochemistry , cancer
In view of carcinoembryonic properties with respect to γ‐GTP, we investigated whether or not hepatoma specific γ‐GTP isoenzyme was found in the sera of patients with hepatoma. Fractionations of serum γ‐GTP were carried out in sera from 229 patients with various hepatobiliary diseases including 68 with hepatoma by polyacrylamide gradient gel electrophoresis. The band II which was seen in the region near to ceruloplasmin could be detected in 25 out of the 68 patients with hepatoma (37%), but not in the patients with other diseases. In addition to the II band, an extra band (II) was found in 15 of these 25 patients. The band II and II′ could not be found in any groups of patients studied except hepatoma patients. It was presumed that band II and II′ could be specific for hepatoma.