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Alpha‐fetoprotein: Is the Pattern of Concanavalin A‐affinity Molecular Variants a Marker for Synthesis by Neoplastic Cells in the Rat?
Author(s) -
KELLEHER P. C.,
McMAHON J. B.,
BARUS M.,
SMITH C. J.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb03947.x
Subject(s) - concanavalin a , microbiology and biotechnology , biology , alpha (finance) , molecular mass , affinity chromatography , catabolism , alpha fetoprotein , secretion , biochemistry , endocrinology , chemistry , metabolism , genetics , in vitro , medicine , enzyme , construct validity , nursing , patient satisfaction , hepatocellular carcinoma
The post‐secretory metabolism of the two concanavalin A‐affinity molecular variants of rat alpha‐fetoprotein was studied in normal adult rats. The serum half‐lives of the two alpha‐fetoprotein molecular variants and unfractionated alpha‐fetoprotein are the same. There is no quantitatively significant interconversion of the two alpha‐fetoprotein concanavalin A‐affinity molecular variants in normal adult rat serum. These results indicate that the pattern of alpha‐fetoprotein concanavalin A‐affinity molecular variants present in rat serum reflects their relative rates of synthesis rather than differences in their rates of catabolism following secretion from the liver cell.