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The in vitro Production of Alpha‐fetoprotein by Human Embryonic Brain
Author(s) -
MACKIEWICZ A.,
HEJDUK W.,
BREBOROWICZ J.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb03926.x
Subject(s) - central nervous system , neural tube , amniotic fluid , embryonic stem cell , in vitro , biology , embryogenesis , alpha fetoprotein , nervous system , fetus , embryo , enteric nervous system , microbiology and biotechnology , neuroscience , pregnancy , biochemistry , cancer research , genetics , gene , hepatocellular carcinoma
The presence of AFP in media of 8 central nervous system monolayer cultures and also in 11 liver and in 11 intestine cultures was detected while it was not detected in placental cultures. We consider these findings as an indirect evidence that AFP (or crossreacting substance) is produced by embryonic central nervous system. The production of AFP by embryonic central nervous system may provide new explanation of elevated AFP concentrations in amniotic fluids of conceptuses with neural tube malformations.