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Complement Activation during Subsequent Stages of Canine Endotoxin Shock
Author(s) -
AASEN A. O.,
MELLBYE O. J.,
OHLSSON K.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00550.x
Subject(s) - shock (circulatory) , complement (music) , immunology , complement system , biology , chemistry , medicine , antibody , biochemistry , phenotype , complementation , gene
Changes in total haemolytic complement and levels of C3, C4 and C6 were studied during subsequent stages of lethal endotoxin shock in dogs. Substantial decreases of all parameters were observed. C4 and C6 decreases showed a very similar pattern, indicating activaiion of complement by the classical pathway in addition to the activation of the alternative pathway known to occur in this pathological condition. The findings emphasize the role of the complement system in the palhophysioiogy of endotoxin shock and are consistent with the concept that complement activation has prognostic value during endotoxacmia.