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Variable‐Region Subgroup and Specificity of Cold Agglutinins
Author(s) -
RIESEN W. F.,
MAJANIEMI I.,
HUSER H.,
BRAUN D. G.,
ROELCKE D.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00506.x
Subject(s) - cold agglutinin , immunoglobulin light chain , antibody , kappa , microbiology and biotechnology , biology , chemistry , mathematics , genetics , geometry
The variable‐region subgroup determined by amino acid sequence analysis of heavy and light chains of two monoclonal cold agglutinins with the new anti‐Gd specificity is reported. Both proteins belong to the VHI 11 subgroup of heavy chains; one light chain falls into the V K I subgroup, the other has a blocked N‐terminus which so far has not been observed in human kappa chains. The comparison of anti‐Gd with anti‐l/‐i or anti‐Pr cold agglutinins indicates that anti‐Gd differs from other cold agglutinins with respect to variable‐region subgroup. The data extend previous findings on the restriction of certain antibodies to distinct variable‐region subgroups.