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Studies on the Structure of T Lymphocyte Receptors using Xenogeneic Anti‐idiotype Antibodies
Author(s) -
RUBIN B.,
HERTELWULFF B.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00488.x
Subject(s) - idiotype , antibody , antiserum , immunization , receptor , immunology , immunoglobulin idiotypes , biology , virology , monoclonal antibody , biochemistry
The present study is an attempt to produce xenogeneic anti‐idiotype antibodies (Id) against mouse anti‐H2 antibodies. The purpose is to obtain such anti‐Id antibodies with reactivity against both B and T cells in quantities which will allow thorough investigation of the biochemical nature of the T cell receptor for alloantigen. Data are presented from experiments performed with an antiserum 5936 which was obtained after immunization with C57B1/6 anti‐CBA antibodies.