Premium
Liver Damage in Mice and Rats Causes Tenfold Increase of Blood Immunoglobulin A
Author(s) -
KAARTINEN M.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00487.x
Subject(s) - carbon tetrachloride , medicine , antibody , immunoglobulin a , endocrinology , chemistry , immunoglobulin m , liver damage , immunoglobulin g , immunology , organic chemistry
Average serum concentrations of IgA and IgM of the SDK rats were 0.27 and 0.43 mg/ml, respectively. Subtotal hepatectomy had no detectable effect on the concentration of IgM but IgA increased in 4 days to a level of 4.9 rag/ml. Thereafter the concentration fell back to normal in 21 days. Serum concentrations of IgA, IgM and IgG2a in (C57BL × CBA)F 1 mice were 0.41, 0.35 and 1.67 mg/ml, respectively. Neither hepatectomy nor carbon tetrachloride poisoning had an effect on the concentrations of IgM or IgG2a but IgA increased to 3.0 mg/ml (hepatectomy) or 3.6 mg/ml (carbon tetrachloride poisoning). Again the increase was reversible. IgA of normal rat serum was mostly monomeric (7S) and of normal mouse serum a mixture 7S and 9S (dimeric) IgA. After liver damage of either type the majority of the serum IgA had a sedimentation constant higher than 7S. It thus resembled the IgA that is brought to the circulation by the thoracic duct of rats and mice.