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Presence of Alloantigen‐Reactive Cells in Neonatally Tolerized Mice
Author(s) -
WATERFIELD J. D.,
BICK P. H.,
MÖLLER E.,
MÖLLER G.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00475.x
Subject(s) - effector , cytotoxic t cell , in vivo , clonal deletion , antigen , in vitro , polyclonal antibodies , biology , immunology , microbiology and biotechnology , t cell , immune system , genetics , t cell receptor
Neonatally induced fully tolerant mice possess cytotoxic effector cells, specific for the tolerizing antigens, which can be induced by polyclonal T cell activators in vivo (Con A) or in vitro (poly A:U). Therefore, clonal deletion of specific effector cells is eliminated as the mechanism by which skin grafts are retained in tolerized mice.