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Stimulating Capacity of Human Lymphoid Cell Subpopulations in Mixed Lymphocyte Cultures
Author(s) -
ALBRECHTSEN D.,
LIED M.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00474.x
Subject(s) - lymphocyte , immunology , lymphatic system , biology , cell , lymphocyte subsets , microbiology and biotechnology , t cell , genetics , immune system
The content and yield of B cells, T cells and monocytes were investigated in cell fractions separated from human peripheral blood by various techniques. These cell fractions, which were highly enriched for either B cells, T cells or monocytes, were tested for their capacity to stimulate allogenic peripheral blood mononuclear cells in mixed lymphocyte cultures (MLC). B cells were found to be strongly stimulatory. Monocytes stimulated strongly at low stimulator responder cell ratios, while less stimulation was observed using larger amounts of cells. T cells were demonstrated to stimulate weakly, if at all.