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The Phagocytosis‐Associated Chemotaxis of Human Mononuclear Leucocytes from Peripheral Blood is not Antitubulin‐Sensitive
Author(s) -
RYDGREN L.,
NORBERG B.,
SVENSSON B.,
SIMMINGSKOELD G.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00452.x
Subject(s) - chemotaxis , phagocytosis , peripheral blood mononuclear cell , peripheral blood , chemotaxis assay , microbiology and biotechnology , biology , immunology , chemistry , in vitro , biochemistry , receptor
Lymphoprep®‐isolated and glass‐adherent mononuclear leucocytes (L‐MNs) from the peripheral blood of healthy donors appeared to display directional locomotion towards sparsely distributed yeast cells during continuous observation in coverslip preparations and during observations by means of time‐lapse filming in Rose chambers. The phagocytosis‐associated L‐MN chemotaxis was not inhibited by antitubulin concentrations which were antichemotactic in parallel experiments by means of Boyden chambers. These observations support the hypothesis that a direct antitubulin‐insensitive chemotaxis exists in L‐MNs, besides the antitubulininhibited L‐MN chemotaxis reported in a previous study.