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Natural and Immune Antibodies to Rabbit Erythrocyte Antigens
Author(s) -
TÖNDER O.,
LARSEN B.,
AARSKOG D.,
HANEBERG B.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00451.x
Subject(s) - antigen , antibody , guinea pig , immunology , trichloroacetic acid , immune system , biology , rabbit (cipher) , biochemistry , endocrinology , statistics , mathematics
Natural agglutinins to rabbit erythrocytes were found in all human sera studied. In the newborn, the antibodies were of IgG class; in the 6‐month‐old infants they were mainly of IgM class. Older children and adults had both IgG and IgM antibodies. Agglutinins to rabbit erythrocytes were also found in serum from fourteen of fifteen other species studied. The trichloroacetic acid extract from rabbit erythrocyte stromata (TCA‐preparation) contains at least three different antigenic determinants: one which we hitherto have found only on rabbit erythrocytes, one which is closely related to human blood group B antigen, and one which is closely related to the I antigen. The TCA‐preparation did not elicit delayed hypersensitivity skin reactions in humans in spite of high titred agglutinins in serum, but did so in immunized guinea‐pigs.