Premium
Platelet Activation: a New Biological Activity of Guinea‐pig C3a Anaphylatoxin
Author(s) -
BECKER S.,
MEUER S.,
HADDING U.,
BITTERSUERMANN D.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00441.x
Subject(s) - anaphylatoxin , platelet , serotonin , guinea pig , chemistry , platelet activation , pharmacology , inducer , biochemistry , immunology , microbiology and biotechnology , antibody , biology , complement system , endocrinology , receptor , gene
3 H‐serotonin‐release from labelled gp‐platelets is established as a sensitive method for testing a new biological activity of gp‐C3a anaphylatoxin in an autologous situation. Time‐, dose‐ and temperature‐dependent release reactions as well as specific inhibition by carboxypeptidase Band anti‐C3a antibodies show that C3a is a potent and specific inducer of platelet activation. Inactive C3a does not induce 3 H‐serotonin‐release but specifically inhibits the action of C3a on platelets.