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Dynamics of the Interaction between Entamoeba histolytica and Components of the Immune Response
Author(s) -
AUSTKETTIS A.,
SUNDQVIST K.G.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00424.x
Subject(s) - cytochalasin b , entamoeba histolytica , colchicine , cytochalasin , immune system , cell , biology , cell membrane , microbiology and biotechnology , redistribution (election) , chemistry , biochemistry , cytoskeleton , immunology , genetics , politics , political science , law
The possible implications of cell membrane dynamics in the host parasite relationship has been studied. Entamoeba histolytica rapidly redistributed and internalized antibodies and Con A bound to its surface. The process was dependent on temperature, cell metabolism and changes of pH in the environment. Phagocytizing amoebae displayed a higher rate of membrane perturbations, which were similarly affected by temperature, cell metabolism and pH variations. Cytochalasin B partially inhibited the redistribution whereas colchicine did not. Colchicine in combination with Cytochalasin B augmented the inhibitory effect of Cytochalasin B alone. The expression of antigens as the surface of the amoeba showed cyclic fluctuations during cell growth.