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Difference in the Effect of Immobilized Ligands on the Fc and C3 Receptors of Mouse Peritoneal Macrophages in Vitro
Author(s) -
KAPLAN G.,
ESKELAND T.,
SELJELID R.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00422.x
Subject(s) - in vitro , receptor , chemistry , peritoneum , immunology , pharmacology , medicine , biochemistry , pathology
The function of the Fc and C3 receptors on the free surface of normal and endotoxin activated mouse peritoneal macrophages seeded on glass bound antibody‐antigen (AbAg) complexes or complement was examined. We found that the glass bound AbAg complexes interfered with attachment and internalization of particles recognized by the Fc receptor. The C3 receptor function in these cells was not affected. On the other hand, normal and activated macrophages seeded on glass bound complement showed no change in the function of the C3 and the Fc receptors.