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T Lymphocyte Recognition of Alloantigen in Vitro
Author(s) -
HERTELWULFF B.,
RUBIN B.
Publication year - 1978
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1978.tb00421.x
Subject(s) - ctl* , cytotoxic t cell , in vitro , cytotoxicity , immunology , t lymphocyte , biology , biochemistry
The present experiments were curried out in order to answer the question whether the precursor T cells of cytotoxic T lymphocytes (PCTL) are Fc receptor positive (FcR + ). Fc receptor negative (FcR − ), or both. The data show that cytotoxic T lymphocytes (CTL) can be generated in vitro from both FcR + and FcR − PCTL. Furthermore, we investigated if the function of FcR + and FcR − CTL differed in the allograft response in vitro. Qualitatively, FcR − PCTL differentiate into FcR − CTL only, whereas FcR + PCTL differentiate into both FcR + and FcR − CTL. However, quantitatively, CTL generated from FcR + PCTL display a higher T cell mediated cytotoxicity than CTL generated from FcR + PCTL. Mixing experiments indicate that FcR + T cells regulate the differentiation of FcR − PCTL into CTL. These conclusions hold true for PCTL in both normal and memory responder cell populations.