Premium
Grenetic Control of Primary and Secondary IgG Responses to Sheep Erythrocytes in Mice
Author(s) -
ANDO I.,
FACHET J.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb02139.x
Subject(s) - primary (astronomy) , immunology , biology , andrology , medicine , physics , astronomy
The genetic control of the primary and secondary IgG responses to sheep erythrocytes has been studied by using inbred, H‐2‐congenic, and intra‐H‐2‐recombinant mouse strains. According to our results, the primary IgG respone is under multi‐genic control. There is a correlation, however, between the titer of primary IgG antibodies produced and the H‐2 phenotypes among the mouse strains tested. One H‐2‐linked gene maps at the I‐B subregion, whereas another gene can be mapped at or closely linked to the H‐2D region. Low and high responsiveness were associated with H‐2 b , H‐2 f and H‐2 a , H‐2 d , H‐2 k phenotypes, respectively. By comparison of the responses of inbred and congenic strains having the same H‐2 phenotype, it can be concluded that background genes influence the primary response only slightly but have almost complete control over the secondary response.