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Emergence of Foreign H‐2‐Like Cytotoxicity and Transplantation Targets on Vaccinia and Moloney Virus‐Infected Meth. A Tumour Cells
Author(s) -
MATOSSIANROGERS A.,
GARRIDO F.,
FESTENSTEIN H.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb02118.x
Subject(s) - vaccinia , virology , cytotoxicity , transplantation , biology , virus , meth , orthopoxvirus , poxviridae , microbiology and biotechnology , medicine , in vitro , chemistry , gene , genetics , organic chemistry , acrylate , surgery , monomer , recombinant dna , polymer
Using cytotoxic effector cells of different anti‐H‐2 specificities, new cell‐mediated lympholysis targets, normally undetected on Meth. A tumour cells, were shown after passage with vaccinia or Moloney virus. The H‐2 d CML targets on Meth.A cells recognized by B10.BR anti‐B10.D2 effector cells were presented only after simultaneous vaccinia virus passage, while passage with Moloney virus caused the emergence of H‐2 b targets. Small but significant killing of vaccinia virus‐passaged Meth.A was also obtained by anti‐H‐2 k effector cells. These results are discussed in relation to in vivo experiments: retardation of tumour growth was noted in mice which had received several injections of vaccinia or Moloney virus, shoving that the new CML targets were probably acting as transplantation targets.