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Population Data on Two New HLA‐D Determinants, El and RE
Author(s) -
GROSSEWILDE H.,
HAUPTMANN G.,
JOHANNSEN R.,
NETZEL B.,
RITTNER C.,
RUPPELT W.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb02114.x
Subject(s) - linkage disequilibrium , human leukocyte antigen , typing , allele , genetics , biology , linkage (software) , population , phenotype , haplotype , demography , antigen , gene , sociology
Homozygous typing cells (HTC) for two new HLA‐D determinants, EI and RE, defined by family studies, are described. The HLA‐D typing experimtens among more than 300 unrelated individuals showed phenotype frequencies of 0.045 for El and 0.098 for RE. Since the tested population was also typed for its HLA‐A and ‐B alleles, linkage disequilibrium parameters could be calculated: HLA‐D type El was statistically significantly associated with HLA‐B13 and Bwl7, HLA‐D type RE with HLA‐Bw40. These data support the working hypothesis that both EI and RE are new alleles of the HLA‐D series.