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Detection of HLA‐D Clusters Using Primed LD Typing
Author(s) -
CROSIER P. S.,
SASPORTES M.,
MAWAS C.,
CHARMOT D.,
DAUSSET J.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb02107.x
Subject(s) - typing , human leukocyte antigen , linkage disequilibrium , biology , antigen , genetics , histocompatibility testing , linkage (software) , tissue typing , immunology , gene , microbiology and biotechnology , allele , haplotype
Using a set of 17 primed LD typing (PLT) cells tested on n panel of 35 unrelated cells, we showed that certain groups of PLT cells tended to detect similar unrelated cells. The PLT cells were grouped into seven clusters and these tended to correlate with the seven HLA‐D specificities represented on the panel, as determined by HTC testing. These data suggest that the antigens that cause restimulation in PLT are similar to those HLA‐D antigens detected by the homozygous typing cell (HTC) test or, alternatively but more unlikely, that the two typing methods are detecting genes in close linkage disequilibrium with the HLA‐D region.