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Oligoclonal IgG and Free Light Chains in the Cerebrospinal Fluid of Patients with Multiple Sclerosis and Infectious Diseases of the Central Nervous System
Author(s) -
VANDVIK B.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00412.x
Subject(s) - subacute sclerosing panencephalitis , multiple sclerosis , cerebrospinal fluid , immunoglobulin light chain , central nervous system , gamma globulin , medicine , pathology , antibody , immunology , immunoelectrophoresis , measles , virology , measles virus , vaccination
Conventional and crossed immunoelectrophoresis were used to characterize oligoclonal γy‐globulin bands of the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) or subacute sclerosing panencephalitis (SSPE) or other infections of the central nervous system. Most γy‐globulin bands were identified as IgG, but some bands were identified as κ or λ, or both, free light chains, Bands of IgG, showed various degrees of light‐chain diversity, and individual bands appeared in many instances to be derived from more than one clone of cells. Sequential changes of the oligoclonal IgG were observed in SSPE but not in MS. Oligoclonal IgG was detected in sera from most patients with SSPE and some patients with MS.