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Immunoglobulins in Families of Myeloma Patients
Author(s) -
FESTEN J. J. M.,
MARRINK J.,
WAARDKUIPER E. H.,
MANDEMA E.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00409.x
Subject(s) - incidence (geometry) , multiple myeloma , antibody , medicine , population , significant difference , immunology , immunoglobulin a , immunoglobulin g , physics , environmental health , optics
The serum immunoglobulin levels of 200 first‐degree relatives and 23 spouses of 32 patients with myelomatosis were compared with those of age‐ and sex‐matched control persons. First‐degree relatives of myeloma patients appeared to have higher serum levels of IgG ( P < 0.05), IgA ( P < 0.05), and IgM ( P < 0.01) than their age‐ and sex‐matched controls. The spouses as a group did not differ from their controls in this respect. No statistically significant difference in the incidence of M‐components among family members (0.6%) and spouses (4.3%) was found compared with the incidence in the general population (0.9%). Myelomatosis as such appeared to be more frequent than in the general population ( P < 0.05).