Premium
Interaction Between a Synthetic Polypeptide, TIGAL, and Fc Receptors on Non‐Bursa‐Derived Chicken Lymphoid Cells
Author(s) -
CRONE M.,
JENSENIUS J. C.,
KOCH C.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00375.x
Subject(s) - antigen , antibody , receptor , in vitro , microbiology and biotechnology , biology , chemistry , immunology , biochemistry
Autoradiographic studies have shown that radioiodinated TIGAL binds in vitro to a small but varying fraction of lymphoid cells from bursectomized, agammaglobulinemic chickens, whereas no binding of radioiodinated TGAL or a variety of other radioiodinated antigens can be observed. The binding of [ 125 I]TIGAL is inhibited by antigen‐antibody complexes, Radioiodinated antigen‐antibody complexes are bound to a similar proportion of the lymphoid cells from bursectomized chickens, and this binding is inhibited by preincubation of the cells with un labeled TIGAL but not with TGAL. These results indicate a cross‐reaction at the level of Fc receptors between determinants on TIGAL and on IgG.