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Inhibition of B‐Cell Function by Concanavalin‐A‐Induced Suppressor Cells
Author(s) -
SHAND F. L.,
IVANYI J.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00373.x
Subject(s) - concanavalin a , suppressor , immune system , in vitro , spleen , antigen , cell , biology , immunology , function (biology) , microbiology and biotechnology , chemistry , biochemistry , gene
The in vitro immune response of normal spleen cells to the thymus‐independent antigen dinitrophenylated levan (DNP‐LE) was found to be inhibited by suppressor cells induced previously by concanavalin A (Con A) in vitro. At various suppressor to target cell ratios, the level of suppression observed was comparable to that seen in anti‐sheep erythrocyte (SRBC) responses. Consequently, it is suggested that B cells constitute a direct target for Con‐A‐induced suppressor cell activity.