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Surface Immunoglobulin Characteristics of B‐Lymphocyte Developmental States and B‐Lymphocyte Colony‐Forming Cells
Author(s) -
HOWARD M. C.,
CLAESSON M. H.,
JOHNSON G. R.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00371.x
Subject(s) - surface immunoglobulin , lymphocyte , immunology , antibody , biology , b cell
B‐lymphocyte colony‐forming cells and various B‐lymphocyte developmental states were examined for expression of surface immunoglobulin. B‐lymphocyte colony forming‐cells appeared to possess a significantly greater amount of surface immunoglobulin than did newborn ‘virgin’ B lymphocytes. In terms of surface immunoglobulin content and physical property characteristics (established previously) B‐lymphocyte colony‐forming Cells resembled a more mature B‐lymphocyte subset. This subset, as characterized in previous studies, consists of mature virgin B cells that develop from the newborn virgin B cells via a process of nonspecific antigen‐induced differentiation. An alternative possibility that B‐lymphocyte colony‐forming cells are memory B lymphocytes has not been eliminated by this study.