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Independent Segregation of Two Functional Markers Expressed on the Same B‐Cell Subset in the Mouse: The Mls Determinants and LPS Receptors
Author(s) -
COUTINHO A.,
MEO T.,
WATANABE T.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00336.x
Subject(s) - receptor , biology , cell , microbiology and biotechnology , computational biology , immunology , genetics
Mice of the C3H/Tif strain display a mixed leukocyte reaction (MLR) with all H‐2 k strains tarrying any of the known alleles of the Mls locus. In particular, C3H/Tif is incompatible with the related substrain C3H/HeJ, from which it also differs at the locus responsible for the recognition of lipopolysaccharides (LPS) as B‐cell mitogens, and at the Mod‐1 locus. Our genetic analysis indicates that the MLR incompatibility between these strains is not H‐2 ‐linked and segregates as controlled by a single locus, most probably identical to Mls , for which the C3H/Tif strain expresses a previously unidentified allele, Mls e . Moreover, segregation data show that this locus assorts independently of LPS responsiveness and that neither marker is closely linked to the Mod‐1 locus in linkage group II.