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Cross‐Idiotypic Reactions Among Anti‐Rh (D) Antibodies
Author(s) -
FøRRE Ø.,
NATVIG J. B.,
MICHAELSEN T. E.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00335.x
Subject(s) - antibody , cross reactions , virology , medicine , immunology , biology
In a series of experiments several idiotype‐specific rabbit antisera produced against different IgG anti‐Rh (D) antibodies reacted with other anti‐Rh (D) antibodies and thus showed cross‐idiotypic reactions. Some of the antisera agglutinated almost all types of anti‐D‐sensitized erythrocytes, whereas other idiotype‐specific antisera agglutinated only a few anti‐D‐sensitized erythrocytes. Anti‐D antibodies showed several different cross‐idiotypic reaction patterns. The cross‐idiotypic antigens were, in most instances, localized to the heavy chains only. In a few cases, however, the cross‐idiotypic antigens were dependent on the interaction between heavy and light chains.