Premium
Characterization of an Inhibitory Allogeneic Effect on Humoral Responsiveness In Vitro
Author(s) -
COHN M.,
EPSTEIN R.
Publication year - 1977
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1977.tb00321.x
Subject(s) - cytotoxic t cell , t cell , cell , antigen , biology , inhibitory postsynaptic potential , microbiology and biotechnology , effector , in vitro , immune system , b cell , antibody , immunology , biochemistry , endocrinology
Evidence is presented that the induction of a humoral response is inhibitable by a thymus‐derived cell (T 1 ) that acts on the antigen‐sensitive precursors of both the thymus‐derived cooperating and the bone marrow‐derived antibody‐secreting cell—that is, the t C and B cell, respectively. The inhibition of induction of the t C and B cell by the T I cell is shown to be reversed by increasing effective level of cooperation. This competitive interaction between the inhibitory (T I ) and cooperating (T C ) systems is postulated to be part of the mechanism for regulating the class of the response, cell‐mediated or humoral. The following properties of the inhibitory system were demonstrated: [1] The t I cell—the antigen‐sensitive precursor of the T I cell—is both paralyzable and inducible. [2] The T I cell appears during the induction of a cell‐mediated response and, if not identical to the effector cytotoxic (‘killer’) T K cell, the T I cell is induced in parallel with it. [3] The effector function of the T I cell, like that of the T K cell, is H‐2‐reitricted.