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Antibody Suppression and Antiallotype Antibodies
Author(s) -
JERNE D.
Publication year - 1976
Publication title -
scandinavian journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.934
H-Index - 88
eISSN - 1365-3083
pISSN - 0300-9475
DOI - 10.1111/j.1365-3083.1976.tb03061.x
Subject(s) - antibody , allotype , context (archaeology) , immunology , medicine , immunoglobulin g , biology , paleontology
Sera from Rh‐sensitized women representing presumable failure of the prophylactic treatment with IgG anti‐D (Rh) have been examined for activity against allotype markers on IgG1. Antiallotype antibodies were found with increased frequency compared with a nonsensitized control. In general, however, interference of antiallotype antibodies is not considered to be a great risk of Rh prophylaxis at present. Some requirements which, in this context, may be of importance to the composition and dose of the IgG anti‐D‐containing preparations used are stressed.